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Next step in HIV microbicide manufacturing begins this summer

April 25, 2011
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PhotoThe Biological Process Development Facility is located in Othmer Hall on the University of Nebraska-Lincoln campus.

Story and photos by Carly Shinn, NewsNetNebraska

Women in countries where AIDS runs rampant may soon get help from the University of Nebraska-Lincoln. Researchers at the school are putting the final touches on a promising cream that could protect against the HIV virus.

2011 marks the 30th anniversary of the AIDS epidemic. Since that time, treatment of the disease has evolved and advocacy and education has become more and more important. The Biological Process Development Facility (BPDF) at UNL is helping in the fight by developing and manufacturing a stable and affordable microbicide to protect women from contracting and spreading HIV.

“The HIV virus is a very complicated guy,” Michael Meager, professor in chemical and biomolecular engineering at UNL and director of the BPDF, said. “He’s got defensive mechanisms to shield himself.”

A microbicide is a compound that protects against infection. The HIV microbicide is a cream designed for vaginal application before intercourse, and the idea is to make one applicator, similar to a tampon, for the price of a cigarette.

“It’s one of the holy grails for AIDS,” Meagher said. “It will be one of multiple tools that will be used to help arrest the disease in developing countries.”

It’s unclear when the cream might go into full-scale production, but manufacturing of test doses is slated to begin by the end of this summer. The microbicide tests are being funded by the Geneva-based Mintaka Foundation of Medical Research, which received its funding from The Wellcome Trust, a global charity based in the United Kingdom. The BPDF received $3.8 million for the project.

According to the Joint United Nations Programme on HIV/AIDS, there are 33.3 million people living with HIV. 22.5 million of those people live in Sub-Saharan Africa, the area Mintaka is targeting.

“Within developed nations, you don’t hear about AIDS or HIV so much anymore,” Meagher said. “It’s not cured, but it’s relatively managed. In developing countries, that’s far from the case.”

Meagher said Mintaka selected the Nebraska facility for the microbicide production because it was impressed by the reputation of the BPDF, which specializes in the development and transition of drugs to phase I clinical trials.

PhotoFermenters are used in the process of producing and manufacturing the HIV microbicide at the facility.

“Nebraska’s not exactly biotech Mecca so to speak,” Meagher said. “But if you have these types of capabilities and you build up the academic side, you have the potential to attract the industries to do that. The goal has always been to build a facility that could compete well in that arena, but also serve as a potential catalyst for companies in the state of Nebraska and as a place to educate the students.”

This philosophy and dedication has helped the BPDF grow into one of the best academic facilities in the United States during its 21 years.

“There are two mottos around here,” Meagher said. “Failure is never an option, and every day we screw up is a day that somebody doesn’t get a needed drug that we’re working on. That’s what we live by.”

According to the U.S. Centers for Disease Control and Prevention, Nebraska is ranked 41st among the 50 states in cumulative reported AIDS cases. With the world focused on growing numbers in developing nations, it is easy to forget about those living with the disease in local communities.

The Nebraska AIDS Project is one organization that’s remembering.

NAP is the only non-profit organization working directly with HIV/AIDS clients in Nebraska. Stephanie Hummer has worked at the Lincoln branch of the project for 10 years and said she has seen a decrease in the stigma associated with HIV/AIDS during that time.

“I have seen a small difference as far as it getting better,” Hummer said. “However, there are still people out there uneducated. I had one client living with people who still made him eat off of paper plates, drink out of paper cups and use plastic utensils. It’s frustrating when you’re willing to go out and educate people and they aren’t willing to listen.”

The HIV microbicide being manufactured at the BPDF would not be available in the U.S. for many years, depending on the success of the trials in Sub-Saharan Africa. Still, there is no denying the benefits it could bring to the global community.

PhotoStephanie Hummer explains the HIV testing process at the Nebraska AIDS Project in Lincoln, Neb.

So what if the microbicide doesn’t work?

Every pharmaceutical drug or vaccine must go through clinical trials. Meagher said only one out of 10 drugs in development make it to the commercial market.

“I think the key thing is if the molecule does show efficacy against the AIDS virus,” Meagher said. “Can I say that 100 percent it’s going to work? No. But the animal studies are pretty convincing and strong in that regard.”

Meagher said early testing done at Mintaka resulted in five out of 10 monkeys being protected from AIDS. He also said the important thing to remember is that with every advancement comes more knowledge and understanding of the problem.

“Hope springs eternal,” Meagher said. “We do what we have to do. The science is the science and then it’s our job to figure out the science and make the adjustments to improve it. We’re not the end game.”

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“King’s Speech” lends a voice to the Science Cafe

April 11, 2011
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PhotoColin Firth in “The King’s Speech.” The movie sheds light on the challenges stutterers face. Photo courtesy of the Weinstein Company.

Story by Carly Shinn, NewsNetNebraska

“I have a voice,” King George VI shouts in the Oscar-winning movie, “The King’s Speech.”

Those four words, part of a climactic scene in the film, also provided a main message for a lecturer in Lincoln at an innovative program aimed at bringing science to the public. Prof. Charles Healey used the phrase at a March 31 Science Cafe program to explain how and why some people stutter.

The University of Nebraska Medical Center started its Science Cafe program in 2009. The cafes involve face-to-face conversations with scientists about current science topics and are held in Omaha, Lincoln and Scottsbluff. The next cafe will be May 3 at The Slowdown in Omaha.

“It’s a great opportunity for the public to hear about science from experts in a very relaxed, comfortable setting,” Healey said. “And it was my first time presenting in a bar.”

Kacie Gerard is a special events associate for UNMC’s public relations department and said science cafes help to bring science literacy to the community.

“People need to know about science and not just from learning about it in the classroom,” Gerard said. “It’s exposing people to things they otherwise wouldn’t be exposed to.”

Healey has worked as a professor of speech-language pathology at the University of Nebraska-Lincoln for more than 33 years. He specializes in stuttering and said “The King’s Speech” has helped to shed light on the challenges stutterers face on a daily basis. The cafe allowed Healey to discuss the advancements in its therapy.

Stutterers and the professionals who work with them, he said, were skeptical at first about the way the disorder would be portrayed in “The King’s Speech.”

“There are a number of movies in Hollywood that have portrayed people who stutter as being of very low intelligence and goofy, neurotic. Or they make fun of them,” Healey said. “Stuttering is not a laughing matter.”

The movie accurately reflected the medical establishment’s view of stuttering in the late 1930s, the speech expert said. Since then, however, specialists in the area look less at such issues as psychological trauma at early ages and more at a broad range of issues including interpersonal relationships, brain chemistry and genetic history. Stuttering, researchers have found, tends to run in families.

Photo
Charles Healey specializes in stuttering at the University of Nebraska-Lincoln. Photo by Carly Shinn

During his presentation, Healey stressed the importance of recognizing the impact stuttering has on the personal lives of individuals.

“As clinicians and specialists, we can’t ignore or diminish the effect stuttering has on their lives,” Healey said.

Education on stuttering has become popular since the release of “The King’s Speech” in 2010 and its Academy Award win for Best Picture earlier this year. Colin Firth’s portrayal of King George VI also earned him the Best Actor award and the stutter Firth produces, according to Healey, is similar to the speaking problems the real king suffered from.

The movie therapist also cast about for successful approaches, something Healey did himself when he first got into the field.

One of Healey’s first clients as a graduate student at the University of Kentucky in 1969 was an adult who stuttered. At the time, no one on the faculty had expertise in working with stutterers and Healey was thrown into it.

“I read as much as I could in books and journals to try and see what I could do to help this individual. I wasn’t coming up with much,” Healey said. “Back then there wasn’t a lot written about treating stuttering. I felt really frustrated that I couldn’t help this individual more than I did.”

After that experience, Healey decided to dedicate his professional career in speech pathology to people who stutter.

The cafe attracted a broad mix of people, ranging from children and parents to speech professionals. One of those in the crowd was Anne Smith, a Purdue University professor who has known Healey for more than 20 years. Her work deals with the physiological aspects of stuttering and she is happy about the effect “The King’s Speech” has had on public education.

“Like Charlie said, it’s brought a lot of positive attention,” Smith said. “People are interested in learning more about stuttering. It’s great.”

Local resident Linda Ager was turned on to the event via UNMC alumni e-mail and said she enjoyed learning about the topic.

“I thought ‘The King’s Speech’ was an incredibly moving and ultimately uplifting movie,” Ager said. “I have great sympathy for stutterers. It’s such a social stigma.”

Duncan Case, a professor in the architecture department at UNL, bemoaned what he saw as the lack of progress in treating stuttering.

“It’s a difficult subject,” Case said. “It looked primitive the way people were treating it back then and apparently they’re still treating it in the same way because it is a difficult thing to understand. It gave me more respect and understanding of the problem.”

Photo
The University of Nebraska Medical Center’s Science Cafe is held at red9 in Lincoln. The program also has events in Omaha and Scottsbluff. Photo by Carly Shinn

Still, Healey has learned a lot over the years and has developed his own perspective on how to assess and treat stuttering. He tries to assess a stutterer’s difficulties from several perspectives, looking at such areas as the physical and social effects, as well as a sufferer’s emotions and attitudes. This differs from the way most speech pathologists view the disorder because it is much broader than focusing, for instance, on the performance of a person’s larynx. Healey said many clinicians only work to treat at a motor level, but that those are simple answers to a very complex problem.

“Simple corrective devices people offer as advice really are not effective at all. The other parts of the system aren’t working,” Healey said.

More than three million people in America stutter according to the National Institute on Deafness and Other Disorders (NIDCD). And while it affects individuals of all ages, stuttering most frequently occurs in children who are developing language. Healey said 98 percent of the people he treats at the UNL Barkley Speech-Language and Hearing Clinic on east campus exhibit developmental stutters, as opposed to neurogenic stutters brought on by stroke, accidents or traumatic events. He encourages anyone dealing with a form of stuttering to contact him or the clinic.

“It’s never too late to work on their stuttering,” Healey said. “I just want to give them a sense of hope.”

Everyone has a voice.



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Drawing from science

March 28, 2011
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Story and photos by Carly Shinn, NewsNetNebraska

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UNL program digs deep

February 28, 2011
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Story and service photos by Carly Shinn, NewsNetNebraska

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State museum celebrates 140 years

February 21, 2011
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Video by Carly Shinn, NewsNetNebraska



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Carly Shinn: social change advocate

January 31, 2011
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Story and Photo by Bethany Trueblood, NewsNetNebraska

Carly Shinn left her home in Lenexa, Kan. to attend the University of Nebraska-Lincoln for something different. Now the junior news-editorial and international studies major is seeking to go somewhere even more unlike what she knows: New Dehli, India.

Shinn, who has never traveled abroad, hopes to be selected to go to India this summer with faculty and students from the College of Journalism and Mass Communications. The two-week trip in July will focus on reporting stories about social issues and poverty in India.  The experience, she said, would help further her career goals.

“I’ve always been focused on humanitarianism and social issues,” said Shinn, who hopes to work with a humanitarianism organization or the government to affect social change. She is also considering joining the Peace Corps after she graduates.

Particular issues she cares about include  the Invisible Children project to free child soldiers in Africa and the global water crisis.



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